Soru 1
In sensory physiology, Pacinian corpuscles detect pressure changes through the activation of specific ion channels. Which type of ion channel is responsible for the initial transduction event in these receptors?
- A
Voltage-gated sodium channels
- B
Ligand-gated sodium channels
- Doğru cevap
Mechanically-gated sodium channels
- D
Voltage-gated calcium channels
- E
Ligand-gated calcium channels
Çözüm
Pacinian corpuscles contain mechanically-gated ion channels that open in response to physical deformation or pressure. This allows sodium ions to enter the cell, generating a receptor potential. The activation is directly linked to mechanical stimuli, distinguishing it from voltage-gated channels (activated by membrane potential changes) and ligand-gated channels (activated by chemical binding). The receptor potential can be quantified, but the core mechanism is mechanical gating, making option C correct.